반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:16][CH2:15][C:10]2(OCC[O:11]2)[CH2:9][CH2:8]1.S(=O)(=O)(O)O.N>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH2:9][C:10](=[O:11])[CH2:15][CH2:16]1참가 물질
4
실험 절차
A solution of 8-(2-pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane (23 g, 0.1 mol) (preparation 36) in 10% w/v sulphuric acid was stirred at room temperature for 8 hr. The reaction mixture was cooled in ice and then the solution adjusted to pH>7 with 0.88 ammonia. The solution was extracted with diethyl ether and the solvent removed from the organic extracts under reduced pressure to give the title compound (14.7 g) as an oil.
후처리
- temperatureThe reaction mixture was cooled in ice
- extractionThe solution was extracted with diethyl ether
- customthe solvent removed from the organic extracts under reduced pressure
출처 및 근거
- ORD 기록
- ord-334b9e7078ef42b789688bc9d55a5949
- 출처 데이터셋
- uspto-grants-2001_12
- 특허 번호
- US06326359B1
연결된 노트
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