Sodium Bicarbonate → HCID 20709190, 화합물

HRID 2268428노트

반응식

HRID 2268428 반응식
CS[C:3]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][N:9]2[CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)=[C:5]([NH:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:4]=1.O[O:28][S:29]([O-:31])=O.[K+].[C:33](=O)([O-])O.[Na+]>>[CH3:33][S:29]([C:3]1[N:11]=[C:10]2[C:6]([N:7]=[CH:8][N:9]2[CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)=[C:5]([NH:18][CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:4]=1)(=[O:31])=[O:28]

참가 물질

4

반응물 3

HCID 516892Sodium BicarbonateHCID 207091892-(Methylsulfanyl)-N-phenethyl-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amineHCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 20709190HCID 20709190, 화합물수율 118.4%

실험 절차

The title compound was prepared by a similar method to preparation 8 from 2-(methylsulfanyl)-N-phenethyl-9-tetrahydro-2H-pyran-2-yl-9H-purin-6-amine (16.7 g, 45 mmol) (preparation 42), Oxone (trade mark) (42.0 g, 136 mmol) and solid sodium hydrogen carbonate (20 g, 238 mmol). This gave the title compound (21.4 g) as a white solid. MS: 402 (MH+).

출처 및 근거

ORD 기록
ord-176d79a468384ac2908b75aeef046f00
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06326359B1

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