Water → 2-(8-Iodooctyl)-4,5,6,7-tetramethoxyindan

HRID 2268473

반응식

HRID 2268473 반응식
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[CH2:22][C:21]2[C:16](=[C:17]([O:29][CH3:30])[C:18]([O:27][CH3:28])=[C:19]([O:25][CH3:26])[C:20]=2[O:23][CH3:24])[CH2:15]1)(=O)=O.[I-:31].[Na+].O>CC(C)=O>[I:31][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH:14]1[CH2:22][C:21]2[C:16](=[C:17]([O:29][CH3:30])[C:18]([O:27][CH3:28])=[C:19]([O:25][CH3:26])[C:20]=2[O:23][CH3:24])[CH2:15]1

참가 물질

5

반응물 3

HCID 962WaterHCID 5238Sodium IodideHCID 183485438-(4,5,6,7-Tetramethoxyindan-2-yl)octyl methanesulfonate

생성물 1

HCID 183485412-(8-Iodooctyl)-4,5,6,7-tetramethoxyindan수율 96.5%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

The mixture of 8-(4,5,6,7-tetramethoxyindan-2-yl)octyl methanesulfonate (2.36 g), sodium iodide (2.38 g) in acetone (20 ml) was heated under reflux for 3 hr. Water was added to the reaction mixture, which was then extracted with ethyl acetate. The organic layer was washed with 5% aqueous sodium sulfite, water, and saturated aqueous sodium chloride, and dried. The solvent was removed in vacuo to yield the entitled compound (2.44 g) as an oil.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hr
  3. extractionwas then extracted with ethyl acetate
  4. washThe organic layer was washed with 5% aqueous sodium sulfite, water, and saturated aqueous sodium chloride
  5. customdried
  6. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-12e43a8690a64c9db37601c105d348df
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06326369B1

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