Sodium Iodide → Ethyl 4-(3-iodopropoxy)benzoate
반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][CH:7]=1.[I-:17].[Na+]>CC(C)=O.O>[I:17][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][CH:7]=1참가 물질
5
실험 절차
The mixture of ethyl 4-(3-chloropropoxy)benzoate (26.5 g), sodium iodide (49.0 g) in acetone (300 ml) was heated under reflux for 24 hr. The reaction mixture was diluted with water and extracted with diethyl ether. The organic layer was washed with 5% aqueous sodium sulfite, water, saturated aqueous sodium chloride, and dried. The solvent was removed in vacuo to yield the entitled compound (34.4 g) as an oil.
후처리
- temperaturewas heated
- temperatureunder reflux for 24 hr
- extractionextracted with diethyl ether
- washThe organic layer was washed with 5% aqueous sodium sulfite, water, saturated aqueous sodium chloride
- customdried
- customThe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-958417d83ed94a4db4d810fec83bf7a6
- 출처 데이터셋
- uspto-grants-2001_12
- 특허 번호
- US06326369B1
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