홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → 6-Amino-9-benzyl-8-hydroxy-2-(3-phthalimidopropylthio)purine

HRID 2269028
노트
인쇄 미리보기

반응식

HRID 2269028 반응식
[NH2:1][C:2]1[N:10]=[C:9]([SH:11])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:19])[N:6]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[C:20](=O)([O-])[O-].[K+].[K+].[C:26]1(=[O:39])[N:30]([CH2:31][CH2:32]Br)[C:29](=[O:34])[C:28]2=[CH:35][CH:36]=[CH:37][CH:38]=[C:27]12>CN(C)C=O>[NH2:1][C:2]1[N:10]=[C:9]([S:11][CH2:20][CH2:32][CH2:31][N:30]2[C:29](=[O:34])[C:28]3=[CH:35][CH:36]=[CH:37][CH:38]=[C:27]3[C:26]2=[O:39])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:19])[N:6]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 11430Potassium CarbonateHCID 1785090596-Amino-9-benzyl-8-hydroxy-2-mercaptopurine

생성물 1

HCID 1785090456-Amino-9-benzyl-8-hydroxy-2-(3-phthalimidopropylthio)purine수율 75%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

6-Amino-9-benzyl-8-hydroxy-2-mercaptopurine (110 mg, 0.40 mmol) was suspended in dimethylformamide (10 ml). To the suspension were added potassium carbonate (50 mg, 0.40 mmol) and 2-phthalimidoethyl bromide (108 mg, 0.40 mmol) in order. The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo, water and methanol were added to the residue, and the resulting crystals were taken by filtration to give the subject compound (138 mg, yield 75%).

후처리

  1. customThe solvent was removed in vacuo, water and methanol
  2. additionwere added to the residue
  3. filtrationthe resulting crystals were taken by filtration

출처 및 근거

ORD 기록
ord-5f1899c1cbe748bbb5bed8fd6977008e
출처 데이터셋
uspto-grants-2001_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06329381B1

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트