Potassium Carbonate → HCID 178509043, 화합물

HRID 2269029

반응식

HRID 2269029 반응식
[NH2:1][C:2]1[N:10]=[C:9]([SH:11])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:19])[N:6]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+].[C:26]1(=[O:41])[N:30]([CH2:31][CH2:32][CH2:33][CH2:34]Br)[C:29](=[O:36])[C:28]2=[CH:37][CH:38]=[CH:39][CH:40]=[C:27]12>CN(C)C=O>[NH2:1][C:2]1[N:10]=[C:9]([S:11][CH2:34][CH2:33][CH2:32][CH2:31][N:30]2[C:26](=[O:41])[C:27]3=[CH:40][CH:39]=[CH:38][CH:37]=[C:28]3[C:29]2=[O:36])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:19])[N:6]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 93575N-(4-Bromobutyl)phthalimideHCID 1785090596-Amino-9-benzyl-8-hydroxy-2-mercaptopurine

생성물 1

HCID 178509043HCID 178509043, 화합물수율 74.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

6-Amino-9-benzyl-8-hydroxy-2-mercaptopurine (120 mg, 0.44 mmol) was suspended in dimethylformamide (10 ml). To the suspension were added potassium carbonate (60 mg, 0.43 mmol) and 4-phthalimidobutyl bromide (113 mg, 0.40 mmol) in order. The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo, and water and methanol were added to the residue, and the resulting crystals were taken by filtration to give the subject compound (141 mg, yield 74%).

후처리

  1. customThe solvent was removed in vacuo, and water and methanol
  2. additionwere added to the residue
  3. filtrationthe resulting crystals were taken by filtration

출처 및 근거

ORD 기록
ord-bb7ba8c4f634447aac52370405f128e4
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329381B1

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