Potassium Carbonate → HCID 178509038, 화합물

HRID 2269051

반응식

HRID 2269051 반응식
[NH2:1][C:2]1[N:10]=[C:9]([SH:11])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:19])[N:6]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:26][C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH2:30]Cl>CN(C)C=O>[NH2:1][C:2]1[N:10]=[C:9]([S:11][CH2:30][C:29]2[CH:32]=[CH:33][CH:34]=[C:27]([Cl:26])[CH:28]=2)[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:19])[N:6]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 12103m,alpha-DichlorotolueneHCID 1785090596-Amino-9-benzyl-8-hydroxy-2-mercaptopurine

생성물 1

HCID 178509038HCID 178509038, 화합물수율 47.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (134 mg, 0.49 mmol) was suspended in dimethylformamide (60 ml). To the suspension were added potassium carbonate (100 mg, 0.72 mmol) and 3-chlorobenzyl chloride (0.09 ml, 0.7 mmol) in order. The mixture was stirred at room temperature for 5 hours. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography (3% methanol/chloroform) to give the subject compound (92 mg, yield 47%).

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by silica gel chromatography (3% methanol/chloroform)

출처 및 근거

ORD 기록
ord-ed16940e7247404883203feb19288133
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329381B1

연결된 노트

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