Hydrochloride methanol → (2S,3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine dihydrochloride

HRID 2269254노트

반응식

HRID 2269254 반응식
[F:1][C:2]([C:5]1[CH:6]=[CH:7][C:8]([O:25][C:26]([F:29])([F:28])[F:27])=[C:9]([CH:24]=1)[CH2:10][NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][NH:14][C@H:13]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([F:4])[CH3:3].CO.[ClH:32]>>[ClH:32].[ClH:32].[F:4][C:2]([C:5]1[CH:6]=[CH:7][C:8]([O:25][C:26]([F:27])([F:28])[F:29])=[C:9]([CH:24]=1)[CH2:10][NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][NH:14][C@H:13]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([F:1])[CH3:3]

참가 물질

3

반응물 2

HCID 21893726Hydrochloride methanolHCID 57090611(2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine

생성물 1

HCID 86757653(2S,3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine dihydrochloride수율 87%

실험 절차

The Compound 27 (360 mg. 0.87 mmol) was treated with methanol-hydrogen chloride (ca 20 ml) and the solvent was evaporated in vacuo to give crude product as a white solid. The crude product was recrystallized from ethanol-diethyl ether to give Compound 28 (370 mg, 87%) as a white solid.

후처리

  1. customthe solvent was evaporated in vacuo
  2. customto give crude product as a white solid
  3. customThe crude product was recrystallized from ethanol-diethyl ether

출처 및 근거

ORD 기록
ord-3987f048170e4a53a966df39d3971fcd
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329396B1

반응 노트

불러오는 중…