HCID 178500760, 화합물 → 3-(3,4-dimethylbenzoyl)-6-fluoroquinolin-4(1H)-one

HRID 226962

반응식

HRID 226962 반응식
CO[C:3](=[O:24])[C:4]([C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[C:17]([CH3:22])[CH:16]=1)=[CH:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1>C1(OC2C=CC=CC=2)C=CC=CC=1.CCCCCC>[CH3:22][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][C:18]=1[CH3:21])[C:14]([C:4]1[C:3](=[O:24])[C:8]2[C:7](=[CH:12][CH:11]=[C:10]([F:13])[CH:9]=2)[NH:6][CH:5]=1)=[O:23]

참가 물질

4

반응물 1

HCID 178500760HCID 178500760, 화합물

생성물 1

HCID 46065703-(3,4-dimethylbenzoyl)-6-fluoroquinolin-4(1H)-one수율 66.1%

시약·촉매·용매 2

HCID 7583Diphenyl Ether용매HCID 8058Hexane용매

실험 절차

0.691 g (2.11 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-(4-fluoro-phenylamino)-acrylic acid methyl ester 2g was dissolved in 30 mL of diphenyl ether and the resultant solution was heated at 250° C. After 2.5 h the solution was cooled to room temperature and diluted with 50 mL of hexane. The crude product precipitated out of solution and was isolated by filtration. The crude product was further washed with hexane to yield 0.412 g of 3-(3,4-dimethyl-benzoyl)-6-fluoro-1H-quinolin-4-one 3j as a brown solid.

후처리

  1. customThe crude product precipitated out of solution
  2. customwas isolated by filtration
  3. washThe crude product was further washed with hexane

출처 및 근거

ORD 기록
ord-07f7734ea7a1418e94850b8843af144c
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557213B2

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