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Dichloromethane → Boc-Thz piperidine

HRID 2269644
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HRID 2269644 반응식
C(Cl)Cl.[N:4]1([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:11][S:10][CH2:9][C@H:5]1[C:6]([OH:8])=[O:7].F[P-](F)(F)(F)(F)F.ClC1N(C)CC[NH+]1C.[NH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1>C(N(CC)CC)C>[N:4]1([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:11][S:10][CH2:9][C@H:5]1[C:6]([OH:8])=[O:7].[NH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 8082PiperidineHCID 688405(4R)-3-[(tert-butoxy)carbonyl]-1,3-thiazolidine-4-carboxylic acidHCID 218684192-Chloro-1,3-dimethylimidazolidin-1-ium;hexafluorophosphate

생성물 1

HCID 131722960Boc-Thz piperidine

시약·촉매·용매 1

HCID 8471
Triethylamine
용매

실험 절차

In a methylene chloride solution containing 300 mg of Boc-Thz-OH, 358 μl of triethylamine, 358 mg of 2-chloro-1, 3-dimethylimidazolidinium hexafluorophosphate and 153 μl of piperidine were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 33 (Process 3) to give 300 mg of the title compound.

후처리

  1. additionwere added under ice cooling
  2. additionThe reaction mixture was treated similarly to that in Example 33 (Process 3)

출처 및 근거

ORD 기록
ord-4c5eb441d9bc4570877ded71086296d7
출처 데이터셋
uspto-grants-2001_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06329502B1

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