Acetonitrile → HCID 21794538, 화합물
반응식
[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]#[N:21].C(#N)C>O>[CH:4]([C:3]1[CH:6]=[CH:7][C:8]([O:10][CH3:11])=[CH:9][C:2]=1[O:1][CH2:19][C:20]#[N:21])=[O:5]참가 물질
6
실험 절차
The mixture of 2-hydroxy-4-methoxybenzaldehyde (9.50 g), potassium carbonate (17.3 g), bromoacetonitrile (11.2 g) and acetonitrile (100 ml) was stirred at room temperature for 12 hours. Water was added to the reaction mixture, which was extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous sodium chloride solution, then dried and concentrated. The residue was purified by alumina column chromatography (eluent: ethyl acetate), and then recrystallized from ethyl acetate-hexane to obtain the entitled compound (10.7 g).
후처리
- extractionwas extracted with ethyl acetate
- washThe organic layer was washed with water
- dry with materiala saturated aqueous sodium chloride solution, then dried
- concentrationconcentrated
- customThe residue was purified by alumina column chromatography (eluent: ethyl acetate)
- customrecrystallized from ethyl acetate-hexane
출처 및 근거
- ORD 기록
- ord-481ef0b581d6449c9e54b2589a22d346
- 출처 데이터셋
- uspto-grants-2001_12
- 특허 번호
- US06329389B1
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