Ethanol → Ethyl 3-[4-(2-benzofuranyl)thiazol-2-yl]propionate

HRID 2269707노트

반응식

HRID 2269707 반응식
Br[CH2:2][C:3]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=1)=O.[CH2:14](O)C.[NH2:17][C:18](=[S:25])[CH2:19][CH2:20][C:21]([O:23][CH3:24])=[O:22]>O>[O:6]1[C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=[C:5]1[C:3]1[N:17]=[C:18]([CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:14])=[O:22])[S:25][CH:2]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 27354511-(1-Benzofuran-2-Yl)-2-Bromoethan-1-OneHCID 18333020Methyl 4-amino-4-thioxobutanoate

생성물 1

HCID 18333015Ethyl 3-[4-(2-benzofuranyl)thiazol-2-yl]propionate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-(Bromoacetyl)benzofuran (650 ml) was added to an ethanol (12 ml) solution of methyl 4-amino-4-thioxobutyrate (400 mg), which was heated under reflux overnight. After cooling, water was added to the reaction mixture, which was extracted with ethyl acetate. The organic layer was dried, concentrated, and then purified by silica gel column chromatography (eluent: hexane/ethyl acetate=4/1). The obtained crystals were washed with hexane to obtain ethyl 3-[4-(2-benzofuranyl)thiazol-2-yl]propionate (460 mg).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux overnight
  3. temperatureAfter cooling
  4. extractionwas extracted with ethyl acetate
  5. customThe organic layer was dried
  6. concentrationconcentrated
  7. custompurified by silica gel column chromatography (eluent: hexane/ethyl acetate=4/1)
  8. washThe obtained crystals were washed with hexane

출처 및 근거

ORD 기록
ord-81ba8f4e2d634cbfbf9dcde51199b65d
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329389B1

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