Hexane → 3-(3,4-Dimethyl-benzoyl)-1H-[1,5]naphthyridin-4-one

HRID 226971

반응식

HRID 226971 반응식
CO[C:3](=[O:23])[C:4]([C:13](=[O:22])[C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[C:16]([CH3:21])[CH:15]=1)=[CH:5][NH:6][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1.CCCCCC>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH3:21][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][C:17]=1[CH3:20])[C:13]([C:4]1[C:3](=[O:23])[C:8]2[C:7](=[CH:12][CH:11]=[CH:10][N:9]=2)[NH:6][CH:5]=1)=[O:22]

참가 물질

4

반응물 2

HCID 8058HexaneHCID 178500765HCID 178500765, 화합물

생성물 1

HCID 577546953-(3,4-Dimethyl-benzoyl)-1H-[1,5]naphthyridin-4-one수율 66.7%

시약·촉매·용매 1

HCID 7583Diphenyl Ether용매

반응 조건

온도
250 °C

실험 절차

1.12 g (3.61 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-(pyridin-3-ylamino)-acrylic acid methyl ester was dissolved in 30 mL of diphenyl ether and the solution was heated at 250° C. After 2.5 h the solution was cooled to rt and 50 mL of hexane was added. The mixture was filtered and the solid washed with hexane to yield 0.67 g of 3-(3,4-Dimethyl-benzoyl)-1H-[1,5]naphthyridin-4-one as a brown solid.

후처리

  1. temperatureAfter 2.5 h the solution was cooled to rt
  2. filtrationThe mixture was filtered
  3. washthe solid washed with hexane

출처 및 근거

ORD 기록
ord-976ea8224a654365a647eaac8a04f01a
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557213B2

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