참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diphenyl Ether | HCID 7583 | — |
| 반응물 | 2,6-Dimethyl-3-pyridylamine | HCID 76964 | — |
| 반응물 | 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester | HCID 66879272 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 3-(3,4-Dimethyl-benzoyl)-6,8-dimethyl-1H-[1,7]naphthyridin-4-one | HCID 57754774 | 7.3% |
반응 단계
0.50 g (2.01 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester and 0.25 g (2.01 mmol) of 2,6-Dimethyl-pyridin-3-ylamine were heated at 100° C. for two hours. After cooling to room temperature 30 mL of diphenyl ether was added and heated at 250° C. for two hours. The reaction was allowed to cool to room temperature and hexane was added. The brown precipitate was collected by filtration to yield 45 mg of 3-(3,4-Dimethyl-benzoyl)-6,8-dimethyl-1H-[1,7]naphthyridin-4-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07557213B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-dc698529e612467bb9d0b10d8a737455 |
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| 출처 메모 | uspto-grants-2009_07 |
|---|
