Boron tribromide → Benzoxazole

HRID 22700

반응식

HRID 22700 반응식
CO[C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9](C3C=CC=C(C(F)(F)F)C=3)=[N:8][C:7]=2[CH:21]=1.B(Br)(Br)Br>C(Cl)Cl>[O:10]1[C:6]2[CH:5]=[CH:4][CH:3]=[CH:21][C:7]=2[N:8]=[CH:9]1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 121354125-Methoxy-2-(3-trifluoromethylphenyl)-benzoxazole

생성물 1

HCID 9228Benzoxazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of compound 10 (200 mg, 0.68 mmol) in CH2Cl2 (5 mL) was added BBr3 (1M in CH2Cl2, 1 mL, 1 mmol) dropwise. The resulting solution was allowed to stir for 48 h. The solvent was removed by evaporation (in vacuo) and the residue was dissolved in ethyl acetate and washed with saturated NaHCO3. The organic layer was dried over MgSO4 and evaporated (in vacuo). The residue was purified using column chromatography (30% ethyl acetate/hexanes) to yield compound 8 as a white solid.

후처리

  1. customThe solvent was removed by evaporation (in vacuo)
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with saturated NaHCO3
  4. dry with materialThe organic layer was dried over MgSO4
  5. customevaporated (in vacuo)
  6. customThe residue was purified

출처 및 근거

ORD 기록
ord-8ac68bc3d6084837bdd5e28d1f8cad1a
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849632B2

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