Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diphenyl Ether → 3-(3-Fluoro-4-methoxy-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diphenyl Ether | HCID 7583 | — |
| 반응물 | 5-Amino-2-methylpyridine | HCID 243313 | — |
| 반응물 | 3-Ethoxy-2-(3-fluoro-4-methoxy-benzoyl)acrylic acid methyl ester | HCID 66879749 | — |
| 생성물 | 3-(3-Fluoro-4-methoxy-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one | HCID 57754627 | 40.1% |
반응 단계
Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.50 g (1.86 mmol) of 3-Ethoxy-2-(3-fluoro-4-methoxy-benzoyl) acrylic acid methyl ester, 0.20 g (1.86 mmol) of 6-Methyl-pyridin-3-ylamine, and 15 mL of diphenyl ether to yield 0.233 g of 3-(3-Fluoro-4-methoxy-benzoyl)-6-methyl-1H-[1,5]naphthyridin-4-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07557213B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-7f3268ff5099482da893501dce9868c8 |
| 출처 메모 | uspto-grants-2009_07 |