Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide → 1-(6-Bromo-pyridin-2-ylmethyl)-3-(3,4-dichloro-benzoyl)-1H-quinolin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide | HCID 57754532 | — |
| 반응물 | HCID 178478192 | HCID 178478192 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(6-Bromo-pyridin-2-ylmethyl)-3-(3,4-dichloro-benzoyl)-1H-quinolin-4-one | HCID 57754600 | — |
반응 단계
Experimental conditions analogous to those described for Step 6 of Example 60 from 90 mg (0.22 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 0.98 mL 0.5M 3,4-dichlorophenylmagnesium bromide. Yield: 64 mg of a white solid. LC-MSD, m/z for C22H13BrCl2N2O2 [M+H]+=487.0, 489.0, 491.0; HPLC retention time: 2.9 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07557213B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-24574779fa8140e599c63b25f42b8698 |
| 출처 메모 | uspto-grants-2009_07 |