Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Iodo-2,6-dimethylpyridine → 1-(6-Bromo-pyridin-2-ylmethyl)-3-(2,6-dimethyl-pyridine-3-carbonyl)-1H-quinolin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Iodo-2,6-dimethylpyridine | HCID 12999944 | — |
| 반응물 | 1-(6-Bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide | HCID 57754532 | — |
| 반응물 | HCID 178418918 | HCID 178418918 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(6-Bromo-pyridin-2-ylmethyl)-3-(2,6-dimethyl-pyridine-3-carbonyl)-1H-quinolin-4-one | HCID 57754656 | — |
반응 단계
Experimental conditions analogous to those described for Step 6 of Example 60 from 105 mg (0.26 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 1 mL THF and 134 mg (0.58 mmol) of 2,6-dimethyl-5-iodo-pyridine in 1 mL THF with 0.30 mL 2M isopropylmagnesium chloride. Yield: 19 mg of a white powder. LC-MSD, m/z for C23H18BrN3O2 [M+H]+=448.0, 450.0; HPLC retention time: 1.2 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07557213B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-8deebccf7b9943799fa99c0200df4d17 |
| 출처 메모 | uspto-grants-2009_07 |