(5-Ethylthiophen-2-yl)boronic acid → HCID 22998405, 화합물

HRID 2270733노트

반응식

HRID 2270733 반응식
[CH2:1]([C:3]1[S:4][C:5](B(O)O)=[CH:6][CH:7]=1)[CH3:2].Br[C:12]1[S:16][C:15]([S:17]([N:20]2[CH:24]=[CH:23][CH:22]=[CH:21]2)(=[O:19])=[O:18])=[CH:14][CH:13]=1>>[CH2:1]([C:3]1[S:4][C:5]([C:12]2[S:16][C:15]([S:17]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)(=[O:18])=[O:19])=[CH:14][CH:13]=2)=[CH:6][CH:7]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 19578941(5-Ethylthiophen-2-yl)boronic acidHCID 23445587N-(5-bromothiophenesulfonyl)pyrrole

생성물 1

HCID 22998405HCID 22998405, 화합물

실험 절차

N-[5-(5-ethyl-2-thienyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 32C from 2-ethylthiophene-5-boronic acid (411 mg, 2.64 mmol) and N-(5-bromothiophene-2-sulfonyl)-pyrrole (700 mg, 2.39 mmol). Purification by column chromatography using 2% ethyl acetate/hexanes gave 630 mg of the pure product as a dark brown solid (90% yield).

후처리

  1. customPurification by column chromatography

출처 및 근거

ORD 기록
ord-67caa014a9c149b09051da84869cc43e
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06331637B1

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