Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → Ethyl 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 반응물 | Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 220876 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 53396422 | 66.6% |
반응 단계
Experimental conditions analogous to those described for Step 3 of Example 1, from 03.00 g (13.8 mmol) of 4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester, 0.66 g (16.6 mmol) of 60% sodium hydride, 2.60 g (16.6 mmol) of 4-methoxybenzyl chloride in 30 mL DMF to give 3.10 g of the product as an off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07557213B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-626ff1b38fe84f43abb9431034bdf698 |
| 출처 메모 | uspto-grants-2009_07 |