Ethyl pyrazinecarboxylate → Ethyl 1,4,5,6-tetrahydropyrazine-2-carboxylate
반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]>CCO.[H][H].[OH-].[OH-].[Pd+2]>[NH:1]1[CH2:6][CH2:5][NH:4][CH:3]=[C:2]1[C:7]([O:9][CH2:10][CH3:11])=[O:8]참가 물질
5
실험 절차
A solution of ethyl pyrazine-2-carboxylate (60 g) in EtOH (500 ml) was subjected to catalytic reduction using palladium hydroxide on carbon (5.0 g), in hydrogen at 3 atm for 4 hours. The catalyst was removed by filtration and the filtrate was concentrated in vacuo to give 62.8 g of ethyl 1,4,5,6-tetrahydropyrazine-2-carboxylate as an oil.
후처리
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-a71465ad30e748fdb1ec4b21f8e27fdd
- 출처 데이터셋
- uspto-grants-2001_12
- 특허 번호
- US06333324B1
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