Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid → Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate | HCID 17879412 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate | HCID 14517129 | 82.6% |
반응 단계
To 5.1 g of diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate were added 20 ml of water and 30 mg of p-toluenesulfonic acid, followed by heating and refluxing for 2.5 hours. After cooling, the mixture was extracted with diethyl ether. The extract was dried over magnesium sulfate and concentrated to give 3.3 g of ethyl 2-methyl-3,4,6-trifluorobenzoylacetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06333431B1 |
| 출처 데이터셋 | uspto-grants-2001_12 |
| ORD ID | ord-991ad80c1386408da891fc79a06e5c96 |
| 출처 메모 | uspto-grants-2001_12 |