1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → HCID 178519813, 화합물

HRID 2271523노트

반응식

HRID 2271523 반응식
C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1.[Br:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33][CH:34]=[C:35]([C:40]([CH:42]2[CH2:44][CH2:43]2)=[O:41])[C:36]([O:38]C)=O)=[CH:29][C:28]=1[F:45]>>[Br:26][C:27]1[CH:32]=[C:31]2[C:30](=[CH:29][C:28]=1[F:45])[N:33]=[CH:34][C:35]([C:40]([CH:42]1[CH2:44][CH2:43]1)=[O:41])=[C:36]2[OH:38]

참가 물질

3

반응물 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 178500751HCID 178500751, 화합물

생성물 1

HCID 178519813HCID 178519813, 화합물수율 79.2%

실험 절차

To Dowtherm at 250° C. was added methyl 3-(4-bromo-3-fluorophenylamino)-2-(cyclopropanecarbonyl)acrylate (7.5 g, 21.9 mmol) portionwise and the reaction mixture was stirred for 1.5 h. The reaction mixture was cooled to room temperature, diluted with hexanes and the resulting precipitate was filtered to afford the desired product (5.38 g, 79%) as a brown solid: ESI MS m/z 311 [C13H9BrFNO2+H]+.

후처리

  1. filtrationthe resulting precipitate was filtered

출처 및 근거

ORD 기록
ord-bed88c9d698b4ce4b419c9ddb8b671bb
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120749B2

반응 노트

불러오는 중…