(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone → HCID 178519796, 화합물

HRID 2271587노트

반응식

HRID 2271587 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.Cl.[N:19]1([C@H:24]2[CH2:29][CH2:28][C@H:27]([NH2:30])[CH2:26][CH2:25]2)[CH2:23][CH2:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:30][C@H:27]1[CH2:26][CH2:25][C@H:24]([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:29][CH2:28]1

참가 물질

3

반응물 2

HCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanoneHCID 178479265HCID 178479265, 화합물

생성물 1

HCID 178519796HCID 178519796, 화합물수율 24%

실험 절차

Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (220 mg, 0.708 mmol) was reacted with trans-4-(pyrrolidin-1-yl)cyclohexanamine hydrochloride (350 mg, 2.08 mmol) to afford the desired product (75 mg, 24%) as an off-white solid: ESI MS m/z 442 [C23H28BrN3O+H]+.

출처 및 근거

ORD 기록
ord-55a6b55476184d4392f678f3f0db32ee
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120749B2

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