2-Chloro-5-nitropyridine → Tert-butyl 1-(5-aminopyridin-2-yl)pyrrolidin-3-ylcarbamate

HRID 2271613노트

반응식

HRID 2271613 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][N:3]=1.[NH:11]1[CH2:15][CH2:14][CH:13]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:12]1>>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH2:15][CH2:14][CH:13]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[CH2:12]2)=[N:3][CH:4]=1

참가 물질

3

반응물 2

HCID 783082-Chloro-5-nitropyridineHCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamate

생성물 1

HCID 53470939Tert-butyl 1-(5-aminopyridin-2-yl)pyrrolidin-3-ylcarbamate수율 94.2%

실험 절차

Following General procedure H, 2-chloro-5-nitropyridine (500 mg, 3.1 mmol) was reacted with tert-butyl pyrrolidin-3-ylcarbamate (931 mg, 5 mmol) followed by reduction to afford the desired product (813 mg, 94%) as a purple solid: ESI MS m/z 279 [C14H22N4O2+H]+.

출처 및 근거

ORD 기록
ord-68390326c7d0458cbcf5cbf91851e544
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120749B2

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