Benzyl alcohol, p-amino-alpha-((dimethylamino)methyl)- → HCID 86692894, 화합물

HRID 2271670노트

반응식

HRID 2271670 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH:25]([OH:30])[CH2:26][N:27]([CH3:29])[CH3:28])=[CH:21][CH:20]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:18][C:19]1[CH:20]=[CH:21][C:22]([CH:25]([OH:30])[CH2:26][N:27]([CH3:28])[CH3:29])=[CH:23][CH:24]=1

참가 물질

3

반응물 2

HCID 54334Benzyl alcohol, p-amino-alpha-((dimethylamino)methyl)-HCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone

생성물 1

HCID 86692894HCID 86692894, 화합물수율 53.5%

실험 절차

Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (240 mg, 0.770 mmol) was reacted with 1-(4-aminophenyl)-2-(dimethylamino)ethanol (139 mg, 0.770 mmol) to afford the desired product (187 mg, 53%) as a yellow solid: ESI MS m/z 454 [C23H24BrN3O2+H]+.

출처 및 근거

ORD 기록
ord-746ed678ec8346e480e826340a520686
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120749B2

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