9-Nitro-5,6-dihydro-benzo[f]quinoline → 9-Amino-5,6-dihydro-benzo[f]quinoline

HRID 2271995노트

반응식

HRID 2271995 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[CH2:16][CH2:15][C:14]3[N:13]=[CH:12][CH:11]=[CH:10][C:9]=3[C:8]=2[CH:17]=1)([O-])=O>[Pd].CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[CH2:16][CH2:15][C:14]3[N:13]=[CH:12][CH:11]=[CH:10][C:9]=3[C:8]=2[CH:17]=1

참가 물질

4

반응물 1

HCID 582946079-Nitro-5,6-dihydro-benzo[f]quinoline

생성물 1

HCID 582945549-Amino-5,6-dihydro-benzo[f]quinoline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 9-nitro-5,6-dihydro-benzo[f]quinoline (1.90 g), 10% palladium on carbon (0.20 g), and methanol (10 mL) is shaken under hydrogen atmosphere (3 bar) at room temperature for 3 h. The catalyst is then separated by filtration and the filtrate is concentrated to give an oil that is submitted to the next reaction without further purification. Yield: 1.67 g (crude); Mass spectrum (ESI+): m/z=197 [M+H]+.

후처리

  1. customThe catalyst is then separated by filtration
  2. concentrationthe filtrate is concentrated
  3. customto give an oil that
  4. customis submitted to the next reaction without further purification

출처 및 근거

ORD 기록
ord-7981e681d9a14fc9847e54ad80e196f7
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120769B2

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