Boron tribromide → 2-(2,4-Dichlorophenyl)benzoxazol-5-ol

HRID 22725

반응식

HRID 22725 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:10][C:11]2[CH:17]=[CH:16][C:15]([O:18]C)=[CH:14][C:12]=2[N:13]=1.B(Br)(Br)Br>ClCCl>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:10][C:11]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:12]=2[N:13]=1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 219116842-(2,4-Dichlorophenyl)-5-methoxybenzoxazole

생성물 1

HCID 219117282-(2,4-Dichlorophenyl)benzoxazol-5-ol

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2-(2,4-dichlorophenyl)-5-methoxybenzoxazole (0.5 g, 1.7 mmol) was dissolved in 25 mL of dichloromethane. To the solution was added BBr3 (8 mmol) and the mixture was stirred at room temperature for 48 hours. The mixture was then diluted with 25 mL dichloromethane, and washed sequentially with saturated NaHCO3 (2×25 mL) and brine. The organic layer was separated, dried over MgSO4 and filtered. The solvent was removed, to provide 2-(2,4-dichlorophenyl)benzoxazol-5-ol, a compound of formula (g), which was purified using flash chromatography.

후처리

  1. washwashed sequentially with saturated NaHCO3 (2×25 mL) and brine
  2. customThe organic layer was separated
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customThe solvent was removed

출처 및 근거

ORD 기록
ord-482f9b27ae834db0a04f5d25e333abc3
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849632B2

연결된 노트

불러오는 중…