Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylalanine amide → Tert-butyl 3-benzyl-2-oxo-1,4,8-triazaspiro[4,5]decane-8-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylalanine amide | HCID 445694 | — |
| 반응물 | tert-Butyl 2-oxopiperidine-1-carboxylate | HCID 7577838 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Tert-butyl 3-benzyl-2-oxo-1,4,8-triazaspiro[4,5]decane-8-carboxylate | HCID 68839899 | — |
반응 단계
N-tert-Butyloxycarbonylpiperidone (6.0 g, 29.8 mmol) was added to a solution of phenylalaninamide (4.9 g, 29.8 mmol) in dry EtOH (20 ml) and the mixture was heated under reflux for 2.5 h. The solvent was removed by distillation, and the tert-butyl 3-benzyl-2-oxo-1,4,8-triazaspiro[4,5]decane-8-carboxylate (10.8 g) was used in the following reaction without further workup.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560468B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-a2d1db906421471b89f7d544cf88dcf8 |
| 출처 메모 | uspto-grants-2009_07 |