Trifluoroacetic acid → HCID 86729754, 화합물

HRID 2272595노트

반응식

HRID 2272595 반응식
[C:1]([C:3]1[CH:23]=[CH:22][C:6]([C:7]([NH:9][CH2:10][CH:11]([CH3:21])[CH2:12][NH:13]C(=O)OC(C)(C)C)=[O:8])=[CH:5][CH:4]=1)#[N:2].C(O)(C(F)(F)F)=O>>[NH2:13][CH2:12][CH:11]([CH3:21])[CH2:10][NH:9][C:7](=[O:8])[C:6]1[CH:22]=[CH:23][C:3]([C:1]#[N:2])=[CH:4][CH:5]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 86729753HCID 86729753, 화합물

생성물 1

HCID 86729754HCID 86729754, 화합물수율 93%

실험 절차

A solution of the compound obtained in Step 1 (311 mg, 0.98 mmol) in TFA (1 mL, 12.98 mmol) was stirred at room temperature for 15 min, and concentrated under reduced pressure. To the residue were added ethyl acetate and 1N aqueous sodium hydroxide solution, and the organic layer was separated. The organic layer was washed with water and saturated brine, and dried, and the solvent was evaporated under reduced pressure to give N-(3-amino-2-methylpropyl)-4-cyanobenzamide (198 mg, 0.911 mmol, 93%) as a white powder.

후처리

  1. concentrationconcentrated under reduced pressure
  2. additionTo the residue were added ethyl acetate and 1N aqueous sodium hydroxide solution
  3. customthe organic layer was separated
  4. washThe organic layer was washed with water and saturated brine
  5. customdried
  6. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ea71da72c2ae484894e00a9812b9d64f
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120776B2

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