Esomeprazole → HCID 178488151, 화합물

HRID 227278

반응식

HRID 227278 반응식
[CH3:1][C:2]1[C:7]([O:8][CH3:9])=[C:6]([CH3:10])[C:5]([CH2:11][S@@:12]([C:14]2[NH:18][C:17]3[CH:19]=[C:20]([O:23][CH3:24])[CH:21]=[CH:22][C:16]=3[N:15]=2)=[O:13])=[N:4][CH:3]=1.[CH:25]1([C@H:31]([NH2:33])[CH3:32])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>C(#N)C>[CH:25]1([C@H:31]([NH3+:33])[CH3:32])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1.[CH3:24][O:23][C:20]1[CH:21]=[CH:22][C:16]2[NH:15][C:14]([S@:12]([CH2:11][C:5]3[C:6]([CH3:10])=[C:7]([O:8][CH3:9])[C:2]([CH3:1])=[CH:3][N:4]=3)=[O:13])=[N:18][C:17]=2[CH:19]=1

참가 물질

4

반응물 2

HCID 9568614EsomeprazoleHCID 10997046(1R)-1-Cyclohexylethanamine

생성물 1

HCID 178488151HCID 178488151, 화합물수율 36.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

(S)-omeprazole (1.0 g, 2.9 mmol) was dissolved in acetonitrile (10 ml). (R)-1-cyclohexyl ethyl amine (0.83 ml, 5.7 mmol) was added to the solution whereupon a white solid precipitated. After 45 minutes acetonitril (10 ml) was added to the thick reaction mass and stirring was continued for 45 minutes. The precipitate was filtered off, washed with acetonitrile, and dried. 0.5 g of the title compound was obtained.

후처리

  1. customprecipitated
  2. additionAfter 45 minutes acetonitril (10 ml) was added to the thick reaction mass
  3. filtrationThe precipitate was filtered off
  4. washwashed with acetonitrile
  5. customdried

출처 및 근거

ORD 기록
ord-ef8b32b7427c427c9f0cb2876b38390a
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560472B2

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