Phenethylamine → (2-Phenylethyl)propylamine
반응식
[C:1]1([CH2:7][CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:10](I)[CH2:11][CH3:12].C(N(CC)CC)C>O1CCCC1>[CH2:10]([NH:9][CH2:8][CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:11][CH3:12]참가 물질
5
실험 절차
1.2 ml (9.5 mmol) of phenylethylamine, 0.93 ml (9.5 mmol) of n-propyl-iodide, 5 ml of triethylamine and 5 ml of THF (tetrahydrofuran) were placed in a flask, and the reaction mixture was heated at reflux temperature of the reaction mixture for 3.5 hours and then cooled. A salt formed was filtered off, the solution was evaporated and a desired compound was purified by column chromatography on silica gel (silica gel 60, mobile phase: CHCl3:CH3OH=10:3). This yields 0.62 g (40%) of N-propyl-(β-phenylethyl)amine in the form of the oil (molecular weight: 163.264, formula: C11H17N).
후처리
- temperaturethe reaction mixture was heated
- temperatureat reflux temperature of the reaction mixture for 3.5 hours
- temperaturecooled
- customA salt formed
- filtrationwas filtered off
- customthe solution was evaporated
- customa desired compound was purified by column chromatography on silica gel (silica gel 60, mobile phase: CHCl3:CH3OH=10:3)
출처 및 근거
- ORD 기록
- ord-782d417f33de43f2bb4ffa61161c59ce
- 출처 데이터셋
- uspto-grants-2009_07
- 특허 번호
- US07560474B2
반응 노트
불러오는 중…