(3S)-2-Carbobenzoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid → (3R)-3-(4-Morpholinylmethyl)-1,2,3,4-tetrahydroisoquinoline

반응식

C(OC([N:11]1[C@H:20]([C:21](O)=O)[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH2:12]1)=O)C1C=CC=CC=1.C(OC([N:34]1[C@@H:43]([C:44]([OH:46])=O)CC2[C:36](=CC=CC=2)[CH2:35]1)=O)C1C=CC=CC=1>>[N:34]1([CH2:21][C@H:20]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12][NH:11]2)[CH2:35][CH2:36][O:46][CH2:44][CH2:43]1

참가 물질

반응물 2

HCID 688307(3S)-2-Carbobenzoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid

HCID 688308Z-D-Tic-OH

생성물 1

HCID 28596893(3R)-3-(4-Morpholinylmethyl)-1,2,3,4-tetrahydroisoquinoline

실험 절차

The procedure is as in the process of Preparation 1′, replacing the (3S)-2-[(benzyloxy)carbonyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid used in Step A by (3R)-2-[(benzyloxy)carbonyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid.

후처리

customThe procedure is as in the process of Preparation 1′,

출처 및 근거

ORD 기록: ord-bef4b09a944e403a8d2b35ca0d155d54
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09120791B2

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