4-Bromophenacyl bromide → HCID 89826358, 화합물

HRID 2272959노트

반응식

HRID 2272959 반응식
C(=O)([O-])[O-].[K+].[K+].[NH:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[C:12]#[N:13].Br[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][CH:19]=1)=[O:17]>CN(C=O)C.ClCCl>[Br:24][C:21]1[CH:22]=[CH:23][C:18]([C:16](=[O:17])[CH2:15][N:7]2[CH:11]=[CH:10][CH:9]=[C:8]2[C:12]#[N:13])=[CH:19][CH:20]=1

참가 물질

6

반응물 3

HCID 74544-Bromophenacyl bromideHCID 11430Potassium CarbonateHCID 138277Pyrrole-2-carbonitrile

생성물 1

HCID 89826358HCID 89826358, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매

실험 절차

5.53 g (40.0 mmol) Potassium carbonate is added to a solution of 1.70 ml (20.0 mmol) pyrrole-2-carbonitrile and 8.34 g (30.0 mmol) 2,4′-dibromoacetophenone in 40 ml DMF. The resulting suspension is stirred for 1 hour at room temperature. The reaction mixture is diluted with dichloromethane and filtered with suction. The residue is washed with dichloromethane. The filtrate is evaporated and the residue is chromatographed on a silica gel column with cyclohexane/ethyl acetate as eluent to give 1-[2-(4-bromo-phenyl)-2-oxo-ethyl]-1H-pyrrole-2-carbonitrile as light orange solid; HPLC/MS 2.80 (B), [M+H] 289/291.

후처리

  1. filtrationfiltered with suction
  2. washThe residue is washed with dichloromethane
  3. customThe filtrate is evaporated
  4. customthe residue is chromatographed on a silica gel column with cyclohexane/ethyl acetate as eluent

출처 및 근거

ORD 기록
ord-a914ffa5054949d3b1bab44b8892ff90
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120805B2

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