Dichloromethane → HCID 178487954, 화합물

HRID 2273237노트

반응식

HRID 2273237 반응식
C([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:19][CH3:20])[N:17]=2)[N:12]=[CH:11][C:10]=1[NH2:21])C1C=CC=CC=1.ClCCl>[Pd].CO>[NH2:21][C:10]1[CH:11]=[N:12][C:13]2[C:18]([C:9]=1[OH:8])=[N:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2

참가 물질

5

반응물 2

HCID 6344DichloromethaneHCID 672542364-Benzyloxy-6-methoxy-[1,5]naphthyridin-3-ylamine

생성물 1

HCID 178487954HCID 178487954, 화합물수율 29%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매2회

실험 절차

10% Palladium on activated carbon (76 mg, 0.07 mmol, 0.1 eq) is added at room temperature to a stirred solution of 4-benzyloxy-6-methoxy-[1,5]naphthyridin-3-ylamine (200 mg, 0.71 mmol, 1.0 eq) in methanol (20 mL). The resulting mixture is stirred under hydrogen flow (3 bars) at room temperature for 16 hours. The catalyst is then removed by filtration and the solution is concentrated to give a residue that is purified by column chromatography (silica gel, eluent: dichloromethane:methanol, 50:1 to 10:1, v/v) to afford 3-amino-6-methoxy-[1,5]naphthyridin-4-ol as a yellow solid (39 mg, 29% yield).

후처리

  1. customThe catalyst is then removed by filtration
  2. concentrationthe solution is concentrated
  3. customto give a residue that
  4. customis purified by column chromatography (silica gel, eluent

출처 및 근거

ORD 기록
ord-8afe5a57b7464442a9addcd2f0231ac4
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120822B2

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