3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 178487811, 화합물

반응식

[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[O:10][CH2:9][CH:8]([C@H:17]3[CH2:22][CH2:21][C@H:20]([NH2:23])[CH2:19][CH2:18]3)[N:7]([CH3:24])[C:6]2=1.[O:25]=[C:26]1[NH:31][C:30]2[CH:32]=[C:33]([C:36](O)=[O:37])[CH:34]=[CH:35][C:29]=2[S:28][CH2:27]1>>[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:14](=[CH:15][CH:16]=1)[N:13]=[CH:12][C:11]1[O:10][CH2:9][CH:8]([C@H:17]3[CH2:22][CH2:21][C@H:20]([NH:23][C:36]([C:33]4[CH:34]=[CH:35][C:29]5[S:28][CH2:27][C:26](=[O:25])[NH:31][C:30]=5[CH:32]=4)=[O:37])[CH2:19][CH2:18]3)[N:7]([CH3:24])[C:6]2=1

참가 물질

반응물 2

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid

HCID 178487810HCID 178487810, 화합물

생성물 1

HCID 178487811HCID 178487811, 화합물

실험 절차

The titled compound is prepared as an orange semisolid following Scheme 5 and in analogy to Example 27 using trans-4-(6-methoxy-4-methyl-3,4-dihydro-2H-1-oxa-4,5,9-triaza-phenanthren-3-yl)-cyclohexylamine and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting materials.

출처 및 근거

ORD 기록: ord-a8c7bb1bbd0d44e38db332ce689ea984
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09120822B2

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