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Water → (3-{3-[4-Amino-3-(methoxycarbonyl)-benzoyl]-2-methylindolizin-1-yl}phenoxy)acetic acid

HRID 2273551
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HRID 2273551 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([C:12]([C:14]2[N:22]3[C:17]([CH:18]=[CH:19][CH:20]=[CH:21]3)=[C:16]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([O:29][CH2:30][C:31]([O:33]C(C)(C)C)=[O:32])[CH:24]=3)[C:15]=2[CH3:38])=[O:13])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].O>FC(F)(F)C(O)=O.ClCCl>[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([C:12]([C:14]2[N:22]3[C:17]([CH:18]=[CH:19][CH:20]=[CH:21]3)=[C:16]([C:23]3[CH:24]=[C:25]([CH:26]=[CH:27][CH:28]=3)[O:29][CH2:30][C:31]([OH:33])=[O:32])[C:15]=2[CH3:38])=[O:13])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]
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참가 물질

5

반응물 2

HCID 962WaterHCID 57500396Methyl 2-amino-5-({1-[3-(2-tert-butoxy-2-oxoethoxy)phenyl]-2-methylindolizin-3-yl}carbonyl)benzoate

생성물 1

HCID 57500399(3-{3-[4-Amino-3-(methoxycarbonyl)-benzoyl]-2-methylindolizin-1-yl}phenoxy)acetic acid수율 92%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid
용매

실험 절차

The solution of 3.68 g (6.65 mmol) of methyl 2-amino-5-({1-[3-(2-tert-butoxy-2-oxoethoxy)phenyl]-2-methylindolizin-3-yl}carbonyl)benzoate in 11 ml of trifluoroacetic acid and 35 ml of dichloromethane at ambient temperature for 4 hours. The reaction medium is poured into water and the mixture is extracted with dichloromethane. The organic phase is partially concentrated, and the yellow precipitate formed is filtered and washed with diisopropyl ether and then dried, to give 2.75 g (92%) of a yellow powder.

후처리

  1. extractionthe mixture is extracted with dichloromethane
  2. concentrationThe organic phase is partially concentrated
  3. customthe yellow precipitate formed
  4. filtrationis filtered
  5. washwashed with diisopropyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-77d8464de035465786e4bd70923a64f7
출처 데이터셋
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09120819B2

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