Isopropylamine → N-Isopropyl 4-bromo-2-nitroaniline

HRID 2273598노트

반응식

HRID 2273598 반응식
[CH:1]([NH2:4])([CH3:3])[CH3:2].[Br:5][C:6]1[CH:11]=[CH:10][C:9](F)=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1>C(O)C>[Br:5][C:6]1[CH:11]=[CH:10][C:9]([NH:4][CH:1]([CH3:3])[CH3:2])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 27363284-Bromo-1-fluoro-2-nitrobenzene

생성물 1

HCID 2759489N-Isopropyl 4-bromo-2-nitroaniline

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Isopropylamine (3 mL) is added to a solution of 4-bromo-1-fluoro-2-nitrobenzene (700 mg, 3.18 mmol) in ethanol. The reaction may be stirred for an appropriate time at an appropriate temperature, such as room temperature for overnight and concentrated. The residue may be purified by any appropriate method such as Biotage column chromatography to give 4-bromo-N-isopropyl-2-nitroaniline (770 mg).

후처리

  1. customThe reaction
  2. concentrationconcentrated
  3. customThe residue may be purified by any appropriate method such as Biotage column chromatography

출처 및 근거

ORD 기록
ord-980a8c9d3e1a4af9b12c51bc77ed8f9e
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09125901B2

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