n-[2-(Ethylamino)ethyl]phthalimide hydrochloride salt → N-[2-(ethylamino)ethyl]phthalimide

HRID 2273613노트

반응식

HRID 2273613 반응식
Cl.[CH2:2]([NH:4][CH2:5][CH2:6][N:7]1[C:11](=[O:12])[C:10]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:9]2[C:8]1=[O:17])[CH3:3]>ClCCl>[CH2:2]([NH:4][CH2:5][CH2:6][N:7]1[C:11](=[O:12])[C:10]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:9]2[C:8]1=[O:17])[CH3:3]

참가 물질

3

반응물 1

HCID 66944064n-[2-(Ethylamino)ethyl]phthalimide hydrochloride salt

생성물 1

HCID 21748445N-[2-(ethylamino)ethyl]phthalimide수율 82.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A suspension of N-[2-(ethylamino)ethyl]phthalimide hydrochloride salt (1) (2.00 g, 7.86 mmol) (Jones, J. H.; Holtz, W. J.; Cragoe, E. J. 6-Substituted 5-chloro-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-ones with hypotensive activity. J. Med. Chem. 1973, 16, 537-42) in dichloromethane (100 mL) was washed with a 5% aqueous sodium carbonate solution (5 mL). The mixture was extracted with dichloromethane (40 mL). The organic layers were combined, dried on magnesium sulfate, filtered and evaporated under vacuum to give compound 2 (1.41 g, 6.47 mmol) as a yellow solid. Yield 82%; mp 111-113° C. (dec.); IR (KBr) ν 1292, 1395, 1430, 1541, 1637, 1712, 2929, 3200-3600 cm−; 1H NMR (200 MHz, CDCl3) δ 1.07 (t, 3H, J=7.1 Hz), 2.68 (q, 2H, J=7.1 Hz), 2.92 (t, 2H, J=6.5 Hz), 3.81 (t, 2H, J=6.5 Hz), 7.68 (m, 2H), 7.82 (m, 2H).

후처리

  1. washwas washed with a 5% aqueous sodium carbonate solution (5 mL)
  2. extractionThe mixture was extracted with dichloromethane (40 mL)
  3. customdried on magnesium sulfate
  4. filtrationfiltered
  5. customevaporated under vacuum

출처 및 근거

ORD 기록
ord-ba18e9ec766f40c8a836881a6ff5a542
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09125937B2

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