Triethylamine → 2-(2,5-dioxopyrrolidin-1-yl)ethyl Methanesulfonate

HRID 227380노트

반응식

HRID 227380 반응식
[OH:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[CH2:7][CH2:6][C:5]1=[O:10].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>C1COCC1>[CH3:18][S:19]([O:1][CH2:2][CH2:3][N:4]1[C:8](=[O:9])[CH2:7][CH2:6][C:5]1=[O:10])(=[O:21])=[O:20]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 236334N-[2-Hydroxyethyl]succinimide

생성물 1

HCID 100822242-(2,5-dioxopyrrolidin-1-yl)ethyl Methanesulfonate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The N-(2-hydroxyethyl)succinimide (Aldrich, 0.19 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

출처 및 근거

ORD 기록
ord-62ec351406f34656b7385cf7e4c342a5
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560481B2

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