4-Methyl-5-(2-hydroxyethyl)thiazole → 5-Thiazoleethanol, 4-methyl-, 5-methanesulfonate

HRID 227381

반응식

HRID 227381 반응식
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH2:7][CH2:8][OH:9].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1COCC1>[CH3:17][S:18]([O:9][CH2:8][CH2:7][C:6]1[S:5][CH:4]=[N:3][C:2]=1[CH3:1])(=[O:20])=[O:19]

참가 물질

5

반응물 3

HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

생성물 1

HCID 101049265-Thiazoleethanol, 4-methyl-, 5-methanesulfonate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The 4-methyl-5-thiazole ethanol (Aldrich, 0.18 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

출처 및 근거

ORD 기록
ord-e3ac47f2f60440cba9fad8d793c7a4e0
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560481B2

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