Aniline → 2-Anilino-2-methylpropiononitrile

HRID 2273884노트

반응식

HRID 2273884 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:8][C:9]([CH3:13])(O)[C:10]#[N:11]>C(OCC)(=O)C>[CH3:8][C:9]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)([CH3:13])[C:10]#[N:11]

참가 물질

4

반응물 2

HCID 6115AnilineHCID 6406Acetone Cyanohydrin

생성물 1

HCID 751282-Anilino-2-methylpropiononitrile수율 94%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of aminobenzene (0.931 g, 10 mmol) and acetone cyanohydrin (2 ml) was heated to reflux and stirred for 20 h. After being cold to room temperature, the reaction mixture was poured into ethyl acetate (40 ml) and washed with cold water (2×30 ml). The organic layer was dried over MgSO4, concentrated under vacuum to dryness to yield 2-methyl-2-phenylaminopropanenitrile, 6a (1.51 g, 9.4 mmol, 94%) as slurry brown liquid.

후처리

  1. temperaturewas heated
  2. temperatureto reflux
  3. customAfter being cold to room temperature
  4. washwashed with cold water (2×30 ml)
  5. dry with materialThe organic layer was dried over MgSO4
  6. concentrationconcentrated under vacuum to dryness

출처 및 근거

ORD 기록
ord-e9510e0c2bdb49dfa5c26b591056a799
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126941B2

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