3-Fluoro-4-nitrobenzene-1-sulfonamide → 4-Amino-3-fluorobenzene-1-sulfonamide

HRID 2273952노트

반응식

HRID 2273952 반응식
[F:1][C:2]1[CH:3]=[C:4]([S:11]([NH2:14])(=[O:13])=[O:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>CO.[Pd]>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([S:11]([NH2:14])(=[O:12])=[O:13])=[CH:3][C:2]=1[F:1]

참가 물질

4

반응물 1

HCID 581586953-Fluoro-4-nitrobenzene-1-sulfonamide

생성물 1

HCID 46874724-Amino-3-fluorobenzene-1-sulfonamide수율 74%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 1.00 g 3-fluoro-4-nitro-benzenesulfonamide in 10 mL MeOH was added 10 mol % of palladium on carbon. The mixture was hydrogenated for 30 minutes at a H2 pressure of 50 psi. After filtration over Hyflo, concentration in vacuo yielded 630 mg (74%) of a dark-brown oil. 1H NMR (400 MHz, DMSO-d6) δ 6.83 (t, J=8.43 Hz, 1H), 7.42 (dd, J=8.28, 1.96 Hz, 1H), 7.47 (dd, J=10.99, 1.96 Hz, 1H) [NH2's invisible].

후처리

  1. filtrationAfter filtration
  2. concentrationover Hyflo, concentration in vacuo

출처 및 근거

ORD 기록
ord-e753274a746845f48220621bce879271
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126942B2

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