Thionyl Chloride → (Tetrahydro-2H-pyran-4-yl)acetyl chloride

HRID 227402

반응식

HRID 227402 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=O)[CH2:3][CH2:2]1.S(Cl)([Cl:13])=O>>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([Cl:13])=[O:10])[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 2773575Tetrahydropyran-4-ylacetic acid

생성물 1

HCID 24229747(Tetrahydro-2H-pyran-4-yl)acetyl chloride

실험 절차

A solution of tetrahydropyran-4-yl acetic acid (Combi-Blocks, Inc., 0.18 g, 1.2 mmol) in thionyl chloride (7 mL, 96 mmol, excess) was refluxed for 1 h then was cooled to ambient temperature and concentrated under reduced pressure. The residue was azeotroped twice with 10 mL of benzene to remove any remaining thionyl chloride. The resulting acid chloride was used without further purification.

후처리

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was azeotroped twice with 10 mL of benzene
  3. customto remove any remaining thionyl chloride
  4. customThe resulting acid chloride was used without further purification

출처 및 근거

ORD 기록
ord-3bf7479e775c4274a3a075fe423aef04
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560481B2

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