Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl indole-6-carboxylate → 3-(2,2,3,3-Tetramethyl-cyclopropanecarbonyl)-1H-indole-6-carboxylic Acid Methyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl indole-6-carboxylate | HCID 639844 | — |
| 반응물 | 2,2,3,3-Tetramethylcyclopropane-1-carbonyl chloride | HCID 11041002 | — |
| 반응물 | HCID 178418443 | HCID 178418443 | — |
| 촉매 | Zincchloride | HCID 3007855 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(2,2,3,3-Tetramethyl-cyclopropanecarbonyl)-1H-indole-6-carboxylic Acid Methyl Ester | HCID 24823931 | 40% |
반응 단계
A mixture of methyl-indole-6-carboxylate (2.0 g, 11.4 mmol), ethylmagnesium bromide (1.0 M solution in THF, 14 mL, 14 mmol), zinc chloride (1.0 M solution in Et2O, 14 mL, 14 mmol) and the product of Example 1A (17 mmol) in 30 mL of dichloromethane was processed as described in Example 1B to provide the title compound (1.35 g, 4.5 mmol, 40% yield). MS (DCI/NH3) m/z 300 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560481B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-845082f05d9a4e1696ef1f36e0648b77 |
| 출처 메모 | uspto-grants-2009_07 |