2,4-Bis(4-methoxybenzyloxy)-7-morpholin-4-ylquinazoline → 7-morpholinoquinazoline-2,4(1H,3H)-dione

HRID 2274140노트

반응식

HRID 2274140 반응식
COC1C=CC(C[O:8][C:9]2[N:18]=[C:17]([O:19]CC3C=CC(OC)=CC=3)[C:16]3[C:11](=[CH:12][C:13]([N:29]4[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)=[CH:14][CH:15]=3)[N:10]=2)=CC=1>Cl.O1CCOCC1>[N:29]1([C:13]2[CH:12]=[C:11]3[C:16]([C:17](=[O:19])[NH:18][C:9](=[O:8])[NH:10]3)=[CH:15][CH:14]=2)[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1

참가 물질

3

반응물 1

HCID 674014182,4-Bis(4-methoxybenzyloxy)-7-morpholin-4-ylquinazoline

생성물 1

HCID 134992987-morpholinoquinazoline-2,4(1H,3H)-dione수율 94.8%

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

232.0 g (0.48 mol) of 2,4-bis(4-methoxybenzyloxy)-7-morpholin-4-ylquinazoline were dissolved in 300 ml of hydrogen chloride/dioxane (4 N) at room temperature and stirred for 3 h. Conventional work-up gave 112.5 g of 7-morpholin-4-yl-1H-quinazoline-2,4-dione; HPLC/MS (M+H)+=248 as solid.

출처 및 근거

ORD 기록
ord-735f5ee22127435cac217eee255b1ba4
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126952B2

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