Morpholine → 6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one

반응식

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1F)[N:8]=[CH:7][NH:6][C:5]2=[O:13].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)[N:8]=[CH:7][NH:6][C:5]2=[O:13]

참가 물질

반응물 2

HCID 8083Morpholine

HCID 1354713086,7-Difluoroquinazolin-4(3H)-one

생성물 1

HCID 1360002446-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one수율 74.8%

반응 조건

온도: 80 °C

실험 절차

37.2 g (0.20 mol) of 6,7-difluoro-3H-quinazolin-4-one were suspended in 70 ml (0.80 mol) of morpholine and stirred at an internal temperature of 80° C. for 16 h. Conventional work-up gave 37.3 g (Y=74%) of 6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one.

출처 및 근거

ORD 기록: ord-d8bd7c471e8e43ab91c17c69264068a9
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09126952B2

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