Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-bromobutanimide → 2-Amino-5-bromo-4-methoxybenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 2-Amino-4-methoxybenzaldehyde | HCID 323503 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Amino-5-bromo-4-methoxybenzaldehyde | HCID 59325258 | 56% |
반응 단계
To a stirred solution of 2-amino-4-methoxybenzaldehyde (6 g, 39.7 mmol) in dichloromethane (100 mL) was added N-bromosuccinimide (7 g, 39.7 mmol). LCMS monitored the reaction until the starting material consumed completely. The reaction mixture was diluted with dichloromethane and water. The separated organic layer was dried sodium sulfate, filtered and concentrated to give the title compound (5 g, 56%) as a yellow solid. MS (ES+) C8H8BrNO2 requires: 229, 231. Found: 230, 232 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09126951B2 |
| 출처 데이터셋 | uspto-grants-2015_09 |
| ORD ID | ord-13f9a284f91e4c41937f53b20427825b |
| 출처 메모 | uspto-grants-2015_09 |