Potassium Carbonate → 4-chloro-2-iodo O-crotyl phenol

HRID 22743

반응식

HRID 22743 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([I:9])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH:17]=[CH:18][CH3:19]>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:16][CH:17]=[CH:18][CH3:19])=[C:4]([I:9])[CH:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 1224142-Butene, 1-bromo-HCID 6202344-Chloro-2-iodophenol

생성물 1

HCID 698740424-chloro-2-iodo O-crotyl phenol수율 95.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a mixture of 4-chloro-2-iodo phenol (5.11 mmol, 1.3 g) in DMF (40 mL) and potassium carbonate (10 mmol, 1.4 g) was added crotyl bromide (10.2 mmol, 1.6 g) and the reaction mixture was stirred at room temperature for one hour. The reaction was quenched with H2O (100 mL) and extracted with EtOAc (2×50 mL). The EtOAc layer was collected, dried, filtered and the filtrate was evaporated to obtain 4-chloro-2-iodo O-crotyl phenol (94%, 1.5 g).

후처리

  1. customThe reaction was quenched with H2O (100 mL)
  2. extractionextracted with EtOAc (2×50 mL)
  3. customThe EtOAc layer was collected
  4. customdried
  5. filtrationfiltered
  6. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-f5692c16398741cabed348cb70f8d640
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849629B2

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