(S)-N-Cbz-1,1-diethoxypropan-2-amine → (2S)-1,1-Diethoxy-2-propanamine

HRID 2274633노트

반응식

HRID 2274633 반응식
[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH:7]C(=O)OCC1C=CC=CC=1)[CH3:6])[CH3:2]>CO.[Pd]>[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C@@H:5]([NH2:7])[CH3:6])[CH3:2]

참가 물질

4

반응물 1

HCID 86652567(S)-N-Cbz-1,1-diethoxypropan-2-amine

생성물 1

HCID 12398111(2S)-1,1-Diethoxy-2-propanamine수율 100.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of (S)-benzyl 1,1-diethoxypropan-2-ylcarbamate (844 mg, 3.00 mmol) in methanol (50 ml) was added 5% palladium on carbon (30 mg) and the mixture was stirred at room temperature for 2 hr under hydrogen atmosphere. The reaction mixture was filtered on Celite and washed with methanol (200 ml) and the filtrate was concentrated in vacuo to obtain the title compound (442 mg, 100%).

후처리

  1. filtrationThe reaction mixture was filtered on Celite
  2. washwashed with methanol (200 ml)
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-1533697070fc4b1390f48a969b4efd4d
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126981B2

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